Thirty years after the infamous DeFeo murders in Amityville, New York, the long-since demolished, famous haunted house has actually been replaced with the High Hopes Psychiatric Hospital. However all is not well with this Amityville Asylum, as recently employed staffer Lisa Templeton begins to experience supernatural encounters. Her reports to the health center administrators are unheeded, and the dark forces impacting the site grow more powerful. Nothing appears to stop the ghouls, and Lisa is quickly defending her life. Can any individual get away the horror that manages the Amityville Asylum?